Biomedical Potential of CAB/CAM

Tissue engineering and nScrypt’s Computer Aided Biology/Computer Aided Machining (CAB/CAM) technology are the result of connecting the engineering sciences with medical science.

The construction of entire organs, once considered science fiction, is now within reach. With the natural extension of CAB/CAM techology, biocompatible, engineered whole organs will be realizable in years as opposed to decades. CAB/CAM will permit developing curative medical treatments and biological constructs. Specifically, engineered neo-organs, that can be used to detect, prevent, and cure diseases. It is our mission that within a decade, we will look back at today’s medical procedures with the same kind of bemusement we now feel for wooden dentures and phrenology maps.

Regenerative medicine is the new frontier, unlocking the code of how the body repairs itself. Biological systems can assemble and repair themselves. The specific architecture of cells and matrix within a tissue provide cues to the body to direct numerous biological functions, such as tissue development, organ formation, wound healing, and homeostasis. We believe that by using CAB/CAM technology to lay down both cells and matrix into in a defined three-dimensional architecture, this new tissue can trigger a response telling the body to repair a diseased kidney or a failing heart.

Simply put, CAB/CAM represents the first real opportunity to offer real-time mass customization of human tissues and organs on demand. We have show that CAB/CAM is able to build precise, three-dimensional biological structures , indicating that it is possible, for the first time to identify and reproduce the mechanisms for growth and repair of human tissues as they occur in nature.

CAB/CAM technology can enable the next wave of discoveries in regenerative medicine and advanced diagnostic therapies. National impact is envisioned through more effective, less costly, progressive health care as well as through increased security gained from the ability to construct immediate cures for weaponized pathogens.

The cost of internal organ replacement is approximately $350 billion worldwide , and this value is rise by 10% each year. That’s almost 8% percent of all health-care spending. At this rate, the economics of healthcare could cripple the country unless fresh ideas are proposed. nScrypt seeks to help in a variety of concrete applications:

  • Spatially organizing and maturing neurons for treatment of Alzheimer’s disease, spinal cord injuries, or Parkinson’s disease;
  • Producing functional heart muscles for congenital heart disorders or for heart-attack victims;
  • Generating tissue containing viable insulin-secreting pancreatic islet cells for treatment of diabetes; and
  • Generating tissue containing dermal papilla or hair-follicle cells for the treatment of baldness.